R&D 中心


研究所介绍-竞争力量

BioNote公司的生命科学研究所是2004年起,被韩国科学技术振兴协会认定
为企业附属研究所。主要负责开发新产品、开发新技术、改善产品等。本研究所
由开发抗原部、开发抗体部、培养及净化部、制药部、分子诊断部组成。为开发出

消费者需求的新产品,不懈的努力,并通过持续改善产品缺点,提高产品的稳定性、特定程度、敏感程度。



Antigen development Team

Antibody Development Team

Culture and purification team

Product Development team

PCR team

 

研究所的竞争力量


本公司研究所是


全球唯一拥有“Gold Conjugate及克隆”生产能力。是在历史上第4位对Gold Conjugate商业化的企业。



拥有“基因重组抗原制造技术”。拥有本公司专有的批量生产用Vector System和蛋白质refolding技术。



拥有制药化的核心技术—批量生产微生物技术、细胞培养技术、酶接合体制造技术、荧光物质接合体制造技术、单克隆抗体生产技术。


以上诉技术为基础,本公司能够最早开发出系列产品。(禽流感快速诊断试剂盒、ELISA试剂盒、布鲁氏菌病快速诊断试剂盒等)

 

发表论文-所获专利

1. Song D, Moon HJ, An DJ, Jeoung HY, Kim H, Yeom MJ, Hong M, Nam JH, Park SJ, Park BK, Oh JS, Song M, Webster RG, Kim JK, Kang BK. A novel reassortant canine H3N1 influenza virus between pandemic H1N1 and canine H3N2 influenza viruses in Korea. J Gen Virol.Mar
93(Pt 3) : 551-4. 2012.
2. Hyungtae Lee, KyoungHwa Jung, Jihyun Park, Gun-woo Ha, Youn-Kyoung Oh, jin-Sik Oh and Young Jyu Chai. Proteomic analysis of the serum from chicken infected by avian influenza virus. J. Bacteriology and virology.
41(3): 195-204.2011.
3. Song DS, An DJ, Moon HJ, Yeom MJ, Jeong HY, Jeong WS, Park SJ, Kim HK, Han SY, Oh JS, Park BK, Kim JK, Pooh, Webster RG, Jung K, Kang BK. Interspecies transmission of the canine influenza H3N2 virus to domestic cats in South Korea, J Gen Viol.
92(Pt 10): 2350-2305. 2011.
4. Song DS, Moon HJ, Jung K, Yeom MJ, Kim HK, Han SY, An DJ, Oh JS, Kim JM, Park BK, Kang BK.. Association between nasal shedding and fever that influenza A (H3N2) induces in dogs.
5. Lee C, Jung K, Oh J, Oh T, Han S, Hwang J, Yeom M, Son D, Kim J, Park B, Moon H, Song D, Kang B. Protective efficacy and immunogenicity of an inactivated avian origin H3N2 canine influenza vaccine in dogs challenged with the virulent virus. Vet Microbiol.
14;143(2-4):184-188.2010.
6. An DJ, Jeoung HY, Jeong W, Chae S, Song DS, Oh JS, Park BK. A serological Survey of Canine Respiratory Coronavirus and Canine Influenza Virus in Korean Dogs. J Vet Med Sci.
7. Choi YJ, Kim HJ, Park JS, Oh MH, Nam HS, Kim YB, Cho BK, Ji MJ, Oh JS.. Evaluation of New Rapid Antigen Test for the Detection of Pandemic Influenza A/H1N1 2009 Virus. J Clin Microbiol.
8. Jeong OM, Kim MC, Kang HM, Ha GW, Oh JS, Yoo JE, Park CH, Kwon JS, Pack MR< Kim HR, Kim YJ, Kwon JH, Lee YJ., Validation of egg yolk antibody based C-ELISA for avian influenza surveillance in breeder duck. Vet Microbiol.
26;144(3-2):287-292.2010
9. Jeong HJ, Song YJ, Lee SW, Lee JB, Park SY, Song CS, Ha GW, Oh JS, Oh YK, Choi IS., Comparative measurement of cell-mediated immune responses of swine to the M and N proteins of porcine reproductive and respiratory syndrome Virus. Clin Vaccine Immunol.
7(4):503-512,2010.
10. Chung TH, Oh JS, Lee YS, Kang KS, Jung JW, Youn HY, Hwang CY, Elevated Serum Levels of S100 Calcium Binding Protein A8 (S100A8) Reflect Disease Severity in Canine Atopic Dermatitis. J Vet Med Sci.
11. Lee C, Jung K, Oh J, Oh T, Han S, Hwang J, Yeom M, Son D, Kim J, Park B, Moon H, Song D, Kang B. Protective Efficacy and immunogenicity of an inactivated avian-origin H3N2 canine influenza vaccine in dogs challenged with the virulent virus. Vet Microbiol.
14;143(2-4):184-188.2010
12. Jung K, Lee CS, Kang BK, Park BK, Oh JS, Song DS. Pathology in dogs with experimental canine H3N2 influenza virus infection. Res Vet Sci.
88(3): 523-525.2009.
13. Song DS, Lee YJ, Jeong OM, Kim YJ, Park CH, Yoo JE, Jeon WJ, Kwon JH, Ha GW, Kang BK, Lee CS, Kim HK, Jung BY, Kim JH, Oh JS. Evaluation of a competitive ELISA for antibody detection against avian influenza virus. J Vet Sci.
10(4): 323-329.2009
14. Zhou SH, Cui SJ, Chen CM, Zhang FC, Li J, Zhou S, Oh JS, Development and validation of an immunogold chro-matographic test for on-farm detection of PRRSV.J Virol Methods.
15. Chulseung Lee, Daesub Song, Bokyu Kang, Dongsuk Kang, Jungeun Yoo, Kwonil Jung, Gunsuk Na, Kichang Lee, Bongkyun Park, Jinsik Oh. A serological survey of avian origin canine H3N2 influenza virus in dogs in Korea. Veterinary Microbiology.
16. Daesub Song, Chulseung Lee, Bokyu Kang, Kwonil Jung, Taehoon Oh, Hyekwon Kim, Bongkyun Park,and Jinsik Oh. Experimental infection of Dogs with Avian- Origin Canine Influenza A Virus (H3N2). Emerging Infection Diseases. 
15(1): 56-58. 2009 
17. Cui S, Zhou S, Chen C, Qi T, Zhang C, Oh J. A simple and rapid immunochromatographic strip test for detecting antibody to porcine reproductive and respiratory syndrome virus.  J Virol Methods.
152(1-2): 38-42.2008
18. Daesub Song, Bokyu Kang, Chulseung Lee, Kwonil Jung, Gunwoo Ha, Dongseok Kang, Seongjun Park, Bongkyun Park, Jinsik Oh. Transmission of Avian Influenza Virus (H3N2) to Dogs. Emerging Infectious Diseases.  
14(5): 741-746, 2008.
19. Kim JW, Lee YJ, Han MY, Bae DH, Jung SC, Oh JS, Ha GW, Cho BK  Evaluation of immunochromatographic assay for serodiagnosis of Brucella canis. J Vet Med Sci.
69(11):1103-7. 2007.
20. Park SJ, Song DS, Ha GW, Park BK. Cloning and further sequence analysis of the spike gene of attenuated porcine epidemic diarrhea virus DR13. Virus Genes.
35(1):55-64. 2007.
21. Kang B, Oh J, Lee C, Park BK, Park Y, Hong K, Lee K, Cho B, Song D. Evaluation of a rapid immunodiagnostic test kit for rabies virus.  J. Virol. Methods.
145(1):30-36, 2007.
22. Jung K, Song DS, Kang BK, Oh JS, Park BK. Serologic surveillance of swine H1 and H3 and avian H5 and H9 influenza A virus infections in swine population in Korea. Prev. Vet. Med.
79:294-303, 2007.
23. Song DS, Lee CS, Jung K, Kang BK, Oh JS, Yoon YD, Lee JH, Park BK. Isolation and phylogenetic analysis of H1N1 swine influenza virus isolated in Korea. Virus Res.
125(1):98-103, 2007.
24. Song DS, Oh JS, Kang BK, Yang JS, Moon HJ, Yoo HS, Jang YS, Park BK. Oral efficacy of Vero cell attenuated porcine epidemic diarrhea virus DR13 strain. Res. Vet. Sci.
82(1):134-140, 2007.
25. Kang BK, Song DS, Jung KI, Lee CS, Park SJ, Oh JS, An DJ, Yang JS, Moon HJ, Lee SS, Yoon YD, Park BK. Genetic characterization of canine rotavirus isolated from a puppy in korea and experimental reproduction of disease. J. Vet. Diagn. Invest.
19(1):78-83, 2007.
26. Song DS, Kang BK, Oh JS, Ha GW, Yang JS, Moon HJ, Jang YS, Park BK.  Multiplex reverse transcription-PCR for rapid differential detection of porcine pidemic diarrhea virus, transmissible gastroenteritis virus, and porcine group A rotavirus. J. Vet. Diagn. Invest.
18(3):278-281, 2006.
27. Oh JS, Ha GW, Cho YS, Kim MJ, An DJ, Hwang KK, Lim YK, Park BK, Kang B, Song DS. One-step immunochromatography assay kit for detecting antibodies to canine parvovirus. Clin. Vaccine Immunol.
13(4):520-524, 2006.
28. Song DS, Kang BK, Lee SS, Yang JS, Moon HJ, Oh JS, Ha GW, Jang YS, Park BK. Use of an internal control in a quantitative RT-PCR assay for quantitation of porcine epidemic diarrhea virus shedding in pigs. J. Virol. Methods.
33(1):27-33, 2006.
29. Oh JS, Song DS, Yang JS, Song JY, Moon HJ, Kim TY, Park BK. Comparison of an enzyme-linked immunosorbent assay with serum neutralization test for serodiagnosis of porcine epidemic diarrhea virus infection. J. Vet. Sci.
6(4):349-352, 2005.
30. DaeSub Song, JinSik Oh, BoKyu Kang, JeongSun Yang, JuYoung Song, HyoungJoon Moon, TaeYung Kim, HanSang Yoo, YongSuk Jang, BongKyun Park. Fecal shedding of a highly cell-culture-adapted porcine epidemic diarrhea virus after oral inoculation pigs. Journal of Swine Health and Production.
13(5):269-272, 2005.
31. Oh JS, Song DS, Yang JS, Song JY, Yoo HS, Jang YS, Park BK. Effect of soluble porcine aminopeptidase N on antibody production against porcine epidemic diarrhea virus. J. Vet. Sci.
5(4):353-357, 2004.
32. Oh JS, Song DS, Park BK. Identification of a putative cellular receptor 150 kDa polypeptide for porcine epidemic diarrhea virus in porcine enterocytes. J. Vet. Sci.
4(3):269-275, 2003.
33. Song DS, Yang JS, Oh JS, Han JH, Park BK. Differentiation of a Vero cell adapted porcine epidemic diarrhea virus from Korean field strains by restriction fragment length polymorphism analysis of ORF3. Vaccine.
21:1833-1742, 2003.
34. Song DS, Lee JY, Oh JS, Lyoo KS, Yoon KJ, Park YH, Park BK. Isolation of H3N2 swine influenza virus in South Korea. J. Vet. Diagn. Invest.
15(1):30-34, 2003.


Patents Status


专利第10-0574559号


免疫层析法犬细小抗体快速诊断试剂盒及其制造方法


专利第10-0593286号


免疫层析法犬瘟热抗体快速诊断试剂盒及其制造方法


专利第10-0762825号


免疫层析法H5亚型高病原禽流感抗原诊断试剂盒及其制造方法

专利第10-0850545


新型犬流感病毒及应对疫苗


专利第10-0954992


利用竞争性酵素免疫测定法的制成的禽流感病毒诊断试剂盒及其检出方法